4cvy: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4cvy' size='340' side='right'caption='[[4cvy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4cvy' size='340' side='right'caption='[[4cvy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cvy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cvy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CVY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvy OCA], [http://pdbe.org/4cvy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cvy RCSB], [http://www.ebi.ac.uk/pdbsum/4cvy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvy OCA], [https://pdbe.org/4cvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cvy RCSB], [https://www.ebi.ac.uk/pdbsum/4cvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/ATSK_MYCTU ATSK_MYCTU]] Alpha-ketoglutarate-dependent sulfate ester dioxygenase, which oxidizes medium-chain alkyl-sulfate esters (PubMed:23762287). Shows preference for 2-ethylhexyl sulfate (2-EHS) in vitro, leading to the formation of succinate and 2-ethylhexanal (PubMed:23762287, PubMed:25427196). Has likely a role in sulfate scavenging in vivo (PubMed:23762287).<ref>PMID:23762287</ref> <ref>PMID:25427196</ref>  Also causes the inactivation of the 2-carboxyquinoxaline Ty38c (an antitubercular compound that inhibits DprE1) via oxidative decarboxylation, using Ty38c instead of alpha-ketoglutarate as a substrate. Is thus responsible for primary resistance of M.tuberculosis to Ty38c in vitro. Overexpression of Rv3406 causes resistance to Ty38c.<ref>PMID:25427196</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 23:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Binda, C]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Brodin, P]]
[[Category: Binda C]]
[[Category: Carta, A]]
[[Category: Brodin P]]
[[Category: Chiarelli, L R]]
[[Category: Carta A]]
[[Category: Cole, S T]]
[[Category: Chiarelli LR]]
[[Category: Costi, M P]]
[[Category: Cole ST]]
[[Category: Delorme, V]]
[[Category: Costi MP]]
[[Category: Dhar, N]]
[[Category: De Rossi E]]
[[Category: Farina, D]]
[[Category: Delorme V]]
[[Category: Ferrari, S]]
[[Category: Dhar N]]
[[Category: Gadupudi, R]]
[[Category: Farina D]]
[[Category: Hartkoorn, R C]]
[[Category: Ferrari S]]
[[Category: Kolly, G S]]
[[Category: Gadupudi R]]
[[Category: Landry, V]]
[[Category: Hartkoorn RC]]
[[Category: Luciani, R]]
[[Category: Kolly GS]]
[[Category: Makarov, V]]
[[Category: Landry V]]
[[Category: Molteni, E]]
[[Category: Luciani R]]
[[Category: Mori, G]]
[[Category: Makarov V]]
[[Category: Neres, J]]
[[Category: Molteni E]]
[[Category: Pasca, M]]
[[Category: Mori G]]
[[Category: Pojer, F]]
[[Category: Neres J]]
[[Category: Porta, A]]
[[Category: Pasca M]]
[[Category: Ribeiro, A L.de Jesus Lopes]]
[[Category: Pojer F]]
[[Category: Riccardi, G]]
[[Category: Porta A]]
[[Category: Rossi, E De]]
[[Category: Riccardi G]]
[[Category: Salina, S]]
[[Category: Salina S]]
[[Category: Saxena, P]]
[[Category: Saxena P]]
[[Category: Venturelli, A]]
[[Category: Venturelli A]]
[[Category: Zanoni, G]]
[[Category: Zanoni G]]
[[Category: Dioxygenase]]
[[Category: De Jesus Lopes Ribeiro AL]]
[[Category: Dpre1]]
[[Category: Drug design]]
[[Category: Mycobacterial enzyme]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/4cvy"