4d1m: Difference between revisions

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<StructureSection load='4d1m' size='340' side='right'caption='[[4d1m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4d1m' size='340' side='right'caption='[[4d1m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d1m]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d1m]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D1M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d1l|4d1l]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1m OCA], [https://pdbe.org/4d1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d1m RCSB], [https://www.ebi.ac.uk/pdbsum/4d1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1m OCA], [http://pdbe.org/4d1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d1m RCSB], [http://www.ebi.ac.uk/pdbsum/4d1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/G1K2L5_DANRE G1K2L5_DANRE]] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).[RuleBase:RU003304]  
[[https://www.uniprot.org/uniprot/G1K2L5_DANRE G1K2L5_DANRE]] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).[RuleBase:RU003304]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Brachidanio rerio]]
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Joerger, A C]]
[[Category: Joerger AC]]
[[Category: P53 family]]
[[Category: Protein evolution]]
[[Category: Tetramer]]
[[Category: Transcription]]
[[Category: Transcription factor]]
[[Category: Tumor suppressor]]
Retrieved from "https://proteopedia.org/4d1m"