4d5s: Difference between revisions
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<StructureSection load='4d5s' size='340' side='right'caption='[[4d5s]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4d5s' size='340' side='right'caption='[[4d5s]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4d5s]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4d5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D5S FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5s OCA], [https://pdbe.org/4d5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d5s RCSB], [https://www.ebi.ac.uk/pdbsum/4d5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5s ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/A49_VACCW A49_VACCW]] Plays a role in the inhibition of host NF-kappa-B activation. Interacts with host BTRC and thereby diminishes ubiquitination of NF-kappa-B inhibitor alpha/NFKBIA. This stabilizes NFKBIA and its interaction with NF-kappaB, so retaining p65/RELA in the cytoplasm and preventing NF-kappa-B-dependent gene expression.<ref>PMID:23468625</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Vaccinia virus | [[Category: Vaccinia virus Western Reserve]] | ||
[[Category: Graham | [[Category: Graham SC]] | ||
[[Category: | [[Category: Maluquer de Motes C]] | ||
[[Category: | [[Category: Mansur DS]] | ||
[[Category: Neidel | [[Category: Neidel S]] | ||
[[Category: Smith | [[Category: Smith GL]] | ||
[[Category: Strnadova | [[Category: Strnadova P]] | ||
