4d7d: Difference between revisions

<table><tr><td colspan='2'>[[4d7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D7D FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PKT:TERT-BUTYL+[(2S)-1-(1H-INDOL-3-YL)-3-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)PROPAN-2-YL]CARBAMATE'>PKT</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7d OCA], [https://pdbe.org/4d7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d7d RCSB], [https://www.ebi.ac.uk/pdbsum/4d7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7d ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>  

*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]

[[Category: Homo sapiens]]

[[Category: Poulos T]]

[[Category: Sevrioukova I]]