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'''Unreleased structure'''


The entry 7poc is ON HOLD  until Paper Publication
==An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles==
 
<StructureSection load='7poc' size='340' side='right'caption='[[7poc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
Authors: Basle, A., Ashley, B., Campopiano, D., Marles-Wright, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7poc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POC FirstGlance]. <br>
Description: An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7poc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7poc OCA], [https://pdbe.org/7poc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7poc RCSB], [https://www.ebi.ac.uk/pdbsum/7poc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7poc ProSAT]</span></td></tr>
[[Category: Ashley, B]]
</table>
[[Category: Campopiano, D]]
== Function ==
[[Category: Basle, A]]
[[https://www.uniprot.org/uniprot/BIKB_THET8 BIKB_THET8]] Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate. It also converts 2-amino-3-ketobutyrate and CoA to glycine and acetyl-CoA. Activity is also observed with the following combinations of substrates: acetyl-CoA and either L-alanine or L-serine, pimeloyl-CoA and either glycine or L-serine, and palmitoyl-CoA with L-alanine.<ref>PMID:18071260</ref>
[[Category: Marles-Wright, J]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Ashley B]]
[[Category: Basle A]]
[[Category: Campopiano D]]
[[Category: Marles-Wright J]]
Retrieved from "https://proteopedia.org/7poc"