7t3j: Difference between revisions
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==Cryo-EM structure of Csy-AcrIF24== | |||
<StructureSection load='7t3j' size='340' side='right'caption='[[7t3j]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t3j]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas Pseudomonas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T3J FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t3j OCA], [https://pdbe.org/7t3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t3j RCSB], [https://www.ebi.ac.uk/pdbsum/7t3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t3j ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/CSY1_PSEAB CSY1_PSEAB]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:21398535</ref> <ref>PMID:22522703</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas]] | |||
[[Category: Chang L]] | |||
[[Category: Mukherjee IA]] | |||
