4d9o: Difference between revisions

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==Structure of ebolavirus protein VP24 from Reston==
==Structure of ebolavirus protein VP24 from Reston==
<StructureSection load='4d9o' size='340' side='right' caption='[[4d9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4d9o' size='340' side='right'caption='[[4d9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebore Ebore]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vne|3vne]], [[3vnf|3vnf]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=129003 EBORE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [http://pdbe.org/4d9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [http://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.  
[[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ebore]]
[[Category: Large Structures]]
[[Category: Zhang, A P.P]]
[[Category: Reston ebolavirus - Reston]]
[[Category: Ebolavirus]]
[[Category: Zhang APP]]
[[Category: Ifn response pathway]]
[[Category: Interferon antagonist]]
[[Category: Karyopherin alpha]]
[[Category: Reston]]
[[Category: Stat1]]
[[Category: Sudan]]
[[Category: Viral protein]]
[[Category: Vp24]]
[[Category: Vp35]]
[[Category: Zaire]]
Retrieved from "https://proteopedia.org/4d9o"