4dm4: Difference between revisions

<StructureSection load='4dm4' size='340' side='right'caption='[[4dm4]], [[Resolution|resolution]] 2.19&Aring;' scene=''>

<table><tr><td colspan='2'>[[4dm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DM4 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dm4 OCA], [https://pdbe.org/4dm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dm4 RCSB], [https://www.ebi.ac.uk/pdbsum/4dm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dm4 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CDC73_YEAST CDC73_YEAST]] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.<ref>PMID:9032243</ref> <ref>PMID:15643076</ref> <ref>PMID:16246725</ref>  

[[Category: Large Structures]]

[[Category: Saccharomyces cerevisiae S288C]]

[[Category: Chen H]]

[[Category: Gao Y]]

[[Category: Li X]]

[[Category: Niu L]]

[[Category: Shi N]]

[[Category: Teng M]]