1ihm: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1ihm.gif|left|200px]] | [[Image:1ihm.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1ihm", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_1ihm| PDB=1ihm | SCENE= }} | |||
}} | |||
'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID''' | '''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID''' | ||
| Line 31: | Line 28: | ||
[[Category: Prasad, B V.]] | [[Category: Prasad, B V.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
[[Category: | [[Category: Beta-barrel]] | ||
[[Category: | [[Category: Ef-tu-like domain caliciviridae]] | ||
[[Category: | [[Category: Icosahedral virus]] | ||
[[Category: | [[Category: T=3 icosahedral capsid]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:00:35 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:00, 2 May 2008
CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID
Overview
Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
About this Structure
1IHM is a Single protein structure of sequence from Norwalk virus. Full crystallographic information is available from OCA.
Reference
X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:10514371 Page seeded by OCA on Fri May 2 20:00:35 2008
