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==Crystal structure at 2.1 A of the S-component for biotin from an ECF-type ABC transporter==
==Crystal structure at 2.1 A of the S-component for biotin from an ECF-type ABC transporter==
<StructureSection load='4dve' size='340' side='right' caption='[[4dve]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
<StructureSection load='4dve' size='340' side='right'caption='[[4dve]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dve]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Laclm Laclm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dve]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_MG1363 Lactococcus lactis subsp. cremoris MG1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DVE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dve OCA], [https://pdbe.org/4dve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dve RCSB], [https://www.ebi.ac.uk/pdbsum/4dve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dve ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioY, llmg_1964 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416870 LACLM])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dve OCA], [http://pdbe.org/4dve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dve RCSB], [http://www.ebi.ac.uk/pdbsum/4dve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dve ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BIOY_LACLM BIOY_LACLM]] Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.  
[[https://www.uniprot.org/uniprot/BIOY_LACLM BIOY_LACLM]] Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[ABC transporter|ABC transporter]]
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Laclm]]
[[Category: Lactococcus lactis subsp. cremoris MG1363]]
[[Category: Beek, J ter]]
[[Category: Large Structures]]
[[Category: Berntsson, R P.A]]
[[Category: Berntsson RP-A]]
[[Category: Duurkens, R]]
[[Category: Duurkens R]]
[[Category: Majsnerowska, M]]
[[Category: Majsnerowska M]]
[[Category: Poolman, B]]
[[Category: Poolman B]]
[[Category: Puri, P]]
[[Category: Puri P]]
[[Category: Slotboom, D J]]
[[Category: Slotboom DJ]]
[[Category: Biotin binding]]
[[Category: Ter Beek J]]
[[Category: Ecf-transport]]
[[Category: Ligand-binding domain]]
[[Category: Membrane]]
[[Category: Transport protein]]
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