7vih: Difference between revisions
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==Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307== | |||
<StructureSection load='7vih' size='340' side='right'caption='[[7vih]], [[Resolution|resolution]] 2.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7vih]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VIH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7I4:1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic+acid'>7I4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vih OCA], [https://pdbe.org/7vih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vih RCSB], [https://www.ebi.ac.uk/pdbsum/7vih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vih ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Gan B]] | |||
[[Category: Ren RB]] | |||
[[Category: Xiao QJ]] | |||
[[Category: Yu LY]] | |||
Revision as of 06:18, 28 September 2022
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
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