7zm2: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "7zm2" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of HsaD from Mycobacterium tuberculosis in complex with Cyclophostin-like inhibitor CyC8b== | |||
<StructureSection load='7zm2' size='340' side='right'caption='[[7zm2]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zm2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZM2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9SW:methoxy-[(3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]pentadecyl]phosphinic+acid'>9SW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zm2 OCA], [https://pdbe.org/7zm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zm2 RCSB], [https://www.ebi.ac.uk/pdbsum/7zm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zm2 ProSAT]</span></td></tr> | ||
[[Category: Cavalier | </table> | ||
[[Category: Roig-Zamboni | == Function == | ||
[[Category: Sulzenbacher | [[https://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU]] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Barelier S]] | |||
[[Category: Cavalier JF]] | |||
[[Category: Roig-Zamboni V]] | |||
[[Category: Sulzenbacher G]] | |||
Revision as of 06:21, 28 September 2022
Crystal structure of HsaD from Mycobacterium tuberculosis in complex with Cyclophostin-like inhibitor CyC8b
| ||||||||||||
