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==Crystal structure of mouse thymidylate synthase in complex with dUMP==
==Crystal structure of mouse thymidylate synthase in complex with dUMP==
<StructureSection load='4e5o' size='340' side='right' caption='[[4e5o]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4e5o' size='340' side='right'caption='[[4e5o]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4e5o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ihh 3ihh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E5O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4e5o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ihh 3ihh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E5O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ihi|3ihi]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e5o OCA], [https://pdbe.org/4e5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e5o RCSB], [https://www.ebi.ac.uk/pdbsum/4e5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e5o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tyms ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e5o OCA], [http://pdbe.org/4e5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e5o RCSB], [http://www.ebi.ac.uk/pdbsum/4e5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e5o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).  
[[https://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Thymidylate synthase]]
[[Category: Mus musculus]]
[[Category: Ciesla, J]]
[[Category: Ciesla J]]
[[Category: Dowiercial, A]]
[[Category: Dowiercial A]]
[[Category: Fraczyk, T]]
[[Category: Fraczyk T]]
[[Category: Jarmula, A]]
[[Category: Jarmula A]]
[[Category: Rode, W]]
[[Category: Rode W]]
[[Category: Rypniewski, W]]
[[Category: Rypniewski W]]
[[Category: Sokolowska, M]]
[[Category: Sokolowska M]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Protein-ligand complex]]
[[Category: Transferase]]
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