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==Crystal structure of beta-parvin CH2 domain==
==Crystal structure of beta-parvin CH2 domain==
<StructureSection load='4edm' size='340' side='right' caption='[[4edm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4edm' size='340' side='right'caption='[[4edm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4edm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EDM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4edm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4edl|4edl]], [[4edn|4edn]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4edm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edm OCA], [https://pdbe.org/4edm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4edm RCSB], [https://www.ebi.ac.uk/pdbsum/4edm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4edm ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARVB, CGI-56 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4edm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edm OCA], [http://pdbe.org/4edm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4edm RCSB], [http://www.ebi.ac.uk/pdbsum/4edm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4edm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARVB_HUMAN PARVB_HUMAN]] Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<ref>PMID:11402068</ref> <ref>PMID:15005707</ref> <ref>PMID:15284246</ref> <ref>PMID:15159419</ref> <ref>PMID:18325335</ref>
[[https://www.uniprot.org/uniprot/PARVB_HUMAN PARVB_HUMAN]] Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<ref>PMID:11402068</ref> <ref>PMID:15005707</ref> <ref>PMID:15284246</ref> <ref>PMID:15159419</ref> <ref>PMID:18325335</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4edm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4edm" style="background-color:#fffaf0;"></div>
==See Also==
*[[Parvin 3D structures|Parvin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Boggon, T J]]
[[Category: Large Structures]]
[[Category: Calderwood, D A]]
[[Category: Boggon TJ]]
[[Category: Chayen, N E]]
[[Category: Calderwood DA]]
[[Category: Draheim, K M]]
[[Category: Chayen NE]]
[[Category: Li, X]]
[[Category: Draheim KM]]
[[Category: Stiegler, A L]]
[[Category: Li X]]
[[Category: Adaptor protein]]
[[Category: Stiegler AL]]
[[Category: Calponin homology domain]]
[[Category: Focal adhesion]]
[[Category: Integrin linked kinase]]
[[Category: Integrin signaling]]
[[Category: Ld motif]]
[[Category: Paxillin]]
[[Category: Protein-protein interaction]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4edm"