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==Crystal Structure of the glycopeptide antibiotic sulfotransferase StaL complexed with A3P and desulfo-A47934.==
==Crystal Structure of the glycopeptide antibiotic sulfotransferase StaL complexed with A3P and desulfo-A47934.==
<StructureSection load='4eec' size='340' side='right' caption='[[4eec]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4eec' size='340' side='right'caption='[[4eec]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eec]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_toyocaensis"_nishimura_et_al. "streptomyces toyocaensis" nishimura et al.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EEC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eec]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_toyocaensis Streptomyces toyocaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EEC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UZ:(2R)-AMINO(3-CHLORO-4-HYDROXYPHENYL)ETHANOIC+ACID'>0UZ</scene>, <scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UZ:(2R)-AMINO(3-CHLORO-4-HYDROXYPHENYL)ETHANOIC+ACID'>0UZ</scene>, <scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eec OCA], [https://pdbe.org/4eec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eec RCSB], [https://www.ebi.ac.uk/pdbsum/4eec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eec ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ovf|2ovf]], [[2ov8|2ov8]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">stal ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=55952 "Streptomyces toyocaensis" Nishimura et al.])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eec OCA], [http://pdbe.org/4eec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eec RCSB], [http://www.ebi.ac.uk/pdbsum/4eec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eec ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/STAL_STRTO STAL_STRTO]] Catalyzes the sulfonation of desulfo-A47934, the final step of A47934 biosynthesis. Has also weak activity in vitro with teicoplanin aglycone and teicoplanin.<ref>PMID:16492565</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces toyocaensis nishimura et al]]
[[Category: Large Structures]]
[[Category: Cygler, M]]
[[Category: Streptomyces toyocaensis]]
[[Category: Shi, R]]
[[Category: Cygler M]]
[[Category: Glycopeptide aglycone complex]]
[[Category: Shi R]]
[[Category: Glycopeptide antibiotic sulfotransferase]]
[[Category: Sulfotransferase]]
[[Category: Transferase-transferase inhibitor complex]]
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