4eg6: Difference between revisions

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<StructureSection load='4eg6' size='340' side='right'caption='[[4eg6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4eg6' size='340' side='right'caption='[[4eg6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eg6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EG6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eg6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EG6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0P5:4-{4-[(1H-BENZIMIDAZOL-2-YLMETHYL)AMINO]-6-(2-CHLORO-4-METHOXYPHENOXY)PYRIMIDIN-2-YL}PIPERAZIN-2-ONE'>0P5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0P5:4-{4-[(1H-BENZIMIDAZOL-2-YLMETHYL)AMINO]-6-(2-CHLORO-4-METHOXYPHENOXY)PYRIMIDIN-2-YL}PIPERAZIN-2-ONE'>0P5</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eg6 OCA], [https://pdbe.org/4eg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eg6 RCSB], [https://www.ebi.ac.uk/pdbsum/4eg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eg6 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eg1|4eg1]], [[4eg3|4eg3]], [[4eg4|4eg4]], [[4eg5|4eg5]], [[4eg7|4eg7]], [[4eg8|4eg8]], [[4ega|4ega]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eg6 OCA], [http://pdbe.org/4eg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4eg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eg6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/Q38C91_TRYB2 Q38C91_TRYB2]]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Methionine--tRNA ligase]]
[[Category: Trypanosoma brucei brucei TREU927]]
[[Category: Fan, E]]
[[Category: Fan E]]
[[Category: Hol, W G.J]]
[[Category: Hol WGJ]]
[[Category: Kim, J E]]
[[Category: Kim JE]]
[[Category: Koh, C Y]]
[[Category: Koh CY]]
[[Category: Shibata, S]]
[[Category: Shibata S]]
[[Category: Verlinde, C L.M J]]
[[Category: Verlinde CLMJ]]
[[Category: Aar]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Ligase]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Metr]]
[[Category: Nucleotide binding]]
[[Category: Parasite]]
[[Category: Protein-inhibitor complex]]
[[Category: Rossmann fold]]
[[Category: Rossmann-fold]]
[[Category: Translation]]
[[Category: Trna binding atp binding]]

Revision as of 07:09, 28 September 2022

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1325

4eg6, resolution 2.90Å

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