4eia: Difference between revisions

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==Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile without nucleotide==
==Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile without nucleotide==
<StructureSection load='4eia' size='340' side='right' caption='[[4eia]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4eia' size='340' side='right'caption='[[4eia]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EIA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eht|4eht]], [[4ehu|4ehu]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eia OCA], [https://pdbe.org/4eia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eia RCSB], [https://www.ebi.ac.uk/pdbsum/4eia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eia ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hadI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eia OCA], [http://pdbe.org/4eia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eia RCSB], [http://www.ebi.ac.uk/pdbsum/4eia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eia ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/HADI_CLODI HADI_CLODI]] Involved in the reductive branch of L-leucine fermentation. Required for the activation of (R)-2-hydroxyisocaproyl-CoA dehydratase. The reduced activator transfers one electron to the dehydratase concomitant with hydrolysis of ATP. This protein is extremely sensitive towards oxygen.<ref>PMID:15654892</ref> <ref>PMID:22827463</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus difficilis hall and o'toole 1935]]
[[Category: Clostridioides difficile]]
[[Category: Dobbek, H]]
[[Category: Large Structures]]
[[Category: Knauer, S H]]
[[Category: Dobbek H]]
[[Category: 2-hydroxyisocaproyl-coa dehydratase binding]]
[[Category: Knauer SH]]
[[Category: Actin fold]]
[[Category: Atp/adp binding]]
[[Category: Atpase]]
[[Category: Electron transfer]]
[[Category: Electron transport]]
Retrieved from "https://proteopedia.org/4eia"