4em4: Difference between revisions

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==Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA==
==Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA==
<StructureSection load='4em4' size='340' side='right' caption='[[4em4]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='4em4' size='340' side='right'caption='[[4em4]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4em4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa3 Staa3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EM4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4em4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_USA300 Staphylococcus aureus subsp. aureus USA300]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EM4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA8:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[4-(phenylsulfonyl)butylamino]propyl]amino]butyl]+hydrogen+phosphate'>CA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA8:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[4-(phenylsulfonyl)butylamino]propyl]amino]butyl]+hydrogen+phosphate'>CA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yqz|1yqz]], [[4em3|4em3]], [[4emw|4emw]], [[4eqr|4eqr]], [[4eqs|4eqs]], [[4eqw|4eqw]], [[4eqx|4eqx]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4em4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4em4 OCA], [https://pdbe.org/4em4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4em4 RCSB], [https://www.ebi.ac.uk/pdbsum/4em4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4em4 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdr, SAUSA300_0873 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367830 STAA3])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CoA-disulfide_reductase CoA-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.14 1.8.1.14] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4em4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4em4 OCA], [http://pdbe.org/4em4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4em4 RCSB], [http://www.ebi.ac.uk/pdbsum/4em4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4em4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CDR_STAA3 CDR_STAA3]] Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide.[HAMAP-Rule:MF_01608]  
[[https://www.uniprot.org/uniprot/CDR_STAA3 CDR_STAA3]] Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide.[HAMAP-Rule:MF_01608]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4em4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4em4" style="background-color:#fffaf0;"></div>
==See Also==
*[[Coenzyme A-Disulfide Reductase|Coenzyme A-Disulfide Reductase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: CoA-disulfide reductase]]
[[Category: Large Structures]]
[[Category: Staa3]]
[[Category: Staphylococcus aureus subsp. aureus USA300]]
[[Category: Claiborne, A]]
[[Category: Claiborne A]]
[[Category: Edwards, J S]]
[[Category: Edwards JS]]
[[Category: Redinbo, M R]]
[[Category: Redinbo MR]]
[[Category: Wallace, B D]]
[[Category: Wallace BD]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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