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==Structure of the type VI peptidoglycan amidase effector Tse1 from Pseudomonas aeruginosa==
==Structure of the type VI peptidoglycan amidase effector Tse1 from Pseudomonas aeruginosa==
<StructureSection load='4eob' size='340' side='right' caption='[[4eob]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
<StructureSection load='4eob' size='340' side='right'caption='[[4eob]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eob]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOB FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1844 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eob OCA], [https://pdbe.org/4eob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eob RCSB], [https://www.ebi.ac.uk/pdbsum/4eob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eob ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eob OCA], [http://pdbe.org/4eob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eob RCSB], [http://www.ebi.ac.uk/pdbsum/4eob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eob ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/TSE1_PSEAE TSE1_PSEAE]] Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria (PubMed:21776080, PubMed:22931054, PubMed:22813741, PubMed:22700987). To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin (PubMed:21776080, PubMed:22931054, PubMed:22700987).<ref>PMID:21776080</ref> <ref>PMID:22700987</ref> <ref>PMID:22813741</ref> <ref>PMID:22931054</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseae]]
[[Category: Large Structures]]
[[Category: Chou, S]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Mougous, J D]]
[[Category: Chou S]]
[[Category: Amidase]]
[[Category: Mougous JD]]
[[Category: Bacteriolytic]]
[[Category: Hydrolase]]
[[Category: Pa1845]]
[[Category: Peptidoglycan degrading]]
[[Category: Protease]]
[[Category: Tsi1]]
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