4esw: Difference between revisions
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==Crystal structure of C. albicans Thi5 H66G mutant== | ==Crystal structure of C. albicans Thi5 H66G mutant== | ||
<StructureSection load='4esw' size='340' side='right' caption='[[4esw]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='4esw' size='340' side='right'caption='[[4esw]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4esw]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4esw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esw OCA], [https://pdbe.org/4esw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esw RCSB], [https://www.ebi.ac.uk/pdbsum/4esw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esw ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/THI5_CANAW THI5_CANAW] Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.<ref>PMID:22568620</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Candida albicans WO-1]] | ||
[[Category: Begley | [[Category: Large Structures]] | ||
[[Category: Ealick | [[Category: Begley TP]] | ||
[[Category: Fenwick | [[Category: Ealick SE]] | ||
[[Category: Hazra | [[Category: Fenwick MK]] | ||
[[Category: Huang | [[Category: Hazra A]] | ||
[[Category: Kinsland | [[Category: Huang S]] | ||
[[Category: Lai | [[Category: Kinsland C]] | ||
[[Category: Philmus | [[Category: Lai R]] | ||
[[Category: Rajashankar | [[Category: Philmus B]] | ||
[[Category: Sanders | [[Category: Rajashankar K]] | ||
[[Category: Zhang | [[Category: Sanders J]] | ||
[[Category: Zhang Y]] | |||
Revision as of 04:13, 7 October 2022
Crystal structure of C. albicans Thi5 H66G mutant
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