4eud: Difference between revisions

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==Succinyl-CoA:acetate CoA-transferase (AarC) in complex with CoA and citrate==
==Succinyl-CoA:acetate CoA-transferase (AarC) in complex with CoA and citrate==
<StructureSection load='4eud' size='340' side='right' caption='[[4eud]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4eud' size='340' side='right'caption='[[4eud]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eud]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"acetimonas_aceti"_(pasteur_1864)_orla-jensen_1909 "acetimonas aceti" (pasteur 1864) orla-jensen 1909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EUD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eu3|4eu3]], [[4eu4|4eu4]], [[4eu5|4eu5]], [[4eu6|4eu6]], [[4eu7|4eu7]], [[4eu8|4eu8]], [[4eu9|4eu9]], [[4eua|4eua]], [[4eub|4eub]], [[4euc|4euc]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eud OCA], [https://pdbe.org/4eud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eud RCSB], [https://www.ebi.ac.uk/pdbsum/4eud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eud ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aarC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinyl-CoA:acetate_CoA-transferase Succinyl-CoA:acetate CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.18 2.8.3.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eud OCA], [http://pdbe.org/4eud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eud RCSB], [http://www.ebi.ac.uk/pdbsum/4eud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eud ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCACT_ACEAC SCACT_ACEAC] Utilizes succinyl-CoA to convert toxic acetate to acetyl-CoA and succinate. Required for growth on acetic acid and for resistance to high levels of acetic acid. Has also low activity with acetoacetate as substrate.<ref>PMID:18502856</ref> <ref>PMID:23030530</ref> <ref>PMID:18502856</ref> [REFERENCE:3]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Succinyl-CoA:acetate CoA-transferase]]
[[Category: Acetobacter aceti]]
[[Category: Kappock, T J]]
[[Category: Large Structures]]
[[Category: Mullins, E A]]
[[Category: Kappock TJ]]
[[Category: Transferase]]
[[Category: Mullins EA]]
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