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==Study on structure and function relationships in human Pirin with Mn ion==
==Study on structure and function relationships in human Pirin with Mn ion==
<StructureSection load='4ewd' size='340' side='right' caption='[[4ewd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='4ewd' size='340' side='right'caption='[[4ewd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ewd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EWD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ewd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ero|4ero]], [[4ewa|4ewa]], [[4ewb|4ewb]], [[4ewe|4ewe]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ewd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewd OCA], [https://pdbe.org/4ewd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ewd RCSB], [https://www.ebi.ac.uk/pdbsum/4ewd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewd ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">human, PIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quercetin_2,3-dioxygenase Quercetin 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.24 1.13.11.24] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ewd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewd OCA], [http://pdbe.org/4ewd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ewd RCSB], [http://www.ebi.ac.uk/pdbsum/4ewd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN]] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
[https://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Quercetin 2,3-dioxygenase]]
[[Category: Large Structures]]
[[Category: Chen, L]]
[[Category: Chen L]]
[[Category: Fu, R]]
[[Category: Fu R]]
[[Category: Liu, A]]
[[Category: Liu A]]
[[Category: Liu, F]]
[[Category: Liu F]]
[[Category: Rehmani, I]]
[[Category: Rehmani I]]
[[Category: Serrano, V]]
[[Category: Serrano V]]
[[Category: Wilson, D W]]
[[Category: Wilson DW]]
[[Category: Beta sandwich]]
[[Category: Cupin]]
[[Category: Metal binding protein]]
[[Category: Nucleus]]
[[Category: Oxidoreductase]]
[[Category: Protein binding]]
[[Category: Transcription cofactor activity]]
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