4ewl: Difference between revisions

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==Crystal Structure of MshB with glycerol and Acetate bound in the active site==
==Crystal Structure of MshB with glycerol and Acetate bound in the active site==
<StructureSection load='4ewl' size='340' side='right' caption='[[4ewl]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4ewl' size='340' side='right'caption='[[4ewl]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ewl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EWL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ewl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mshB, MT1207, Rv1170 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewl OCA], [https://pdbe.org/4ewl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ewl RCSB], [https://www.ebi.ac.uk/pdbsum/4ewl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewl ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside_deacetylase N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.103 3.5.1.103] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewl OCA], [http://pdbe.org/4ewl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ewl RCSB], [http://www.ebi.ac.uk/pdbsum/4ewl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MSHB_MYCTU MSHB_MYCTU]] Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol (MSH) biosynthesis pathway. Shows some amidase activity toward S-conjugates of mycothiol.<ref>PMID:11092856</ref>
[https://www.uniprot.org/uniprot/MSHB_MYCTU MSHB_MYCTU] Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol (MSH) biosynthesis pathway. Shows some amidase activity toward S-conjugates of mycothiol.<ref>PMID:11092856</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase]]
[[Category: Large Structures]]
[[Category: Broadley, S G]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Marakalala, M J]]
[[Category: Broadley SG]]
[[Category: Sewell, B T]]
[[Category: Marakalala MJ]]
[[Category: Steenkamp, D J]]
[[Category: Sewell BT]]
[[Category: Weber, B W]]
[[Category: Steenkamp DJ]]
[[Category: Acetate]]
[[Category: Weber BW]]
[[Category: Active site]]
[[Category: Glycerol]]
[[Category: Histidine 144]]
[[Category: Hydrolase]]
[[Category: Mshb]]
[[Category: Tyrosine 142]]
Retrieved from "https://proteopedia.org/4ewl"