4ews: Difference between revisions

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<StructureSection load='4ews' size='340' side='right'caption='[[4ews]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='4ews' size='340' side='right'caption='[[4ews]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ews]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EWS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ews]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0RP:ETHYL+(2R,4S)-4-{[3,5-BIS(TRIFLUOROMETHYL)BENZYL](METHOXYCARBONYL)AMINO}-2-ETHYL-6-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE'>0RP</scene>, <scene name='pdbligand=2OB:CHOLESTERYL+OLEATE'>2OB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DLP:1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>DLP</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RP:ETHYL+(2R,4S)-4-{[3,5-BIS(TRIFLUOROMETHYL)BENZYL](METHOXYCARBONYL)AMINO}-2-ETHYL-6-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE'>0RP</scene>, <scene name='pdbligand=2OB:CHOLESTERYL+OLEATE'>2OB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DLP:1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>DLP</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2obd|2obd]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ews OCA], [https://pdbe.org/4ews PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ews RCSB], [https://www.ebi.ac.uk/pdbsum/4ews PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ews ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ews OCA], [http://pdbe.org/4ews PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ews RCSB], [http://www.ebi.ac.uk/pdbsum/4ews PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ews ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[http://omim.org/entry/143470 143470]]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref> <ref>PMID:8408659</ref> <ref>PMID:12091484</ref>
[https://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[https://omim.org/entry/143470 143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref> <ref>PMID:8408659</ref> <ref>PMID:12091484</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.  
[https://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Liu, S]]
[[Category: Liu S]]
[[Category: Qiu, X]]
[[Category: Qiu X]]
[[Category: Cholestryl ester transfer protein]]
[[Category: Cholestryl ester transfer protein-inhibitor complex]]
[[Category: High-density lipoprotein]]
[[Category: Lipid transport-inhibitor complex]]
[[Category: Low-density lipoprotein]]