4f11: Difference between revisions

<StructureSection load='4f11' size='340' side='right'caption='[[4f11]], [[Resolution|resolution]] 2.38&Aring;' scene=''>

<table><tr><td colspan='2'>[[4f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F11 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f11 OCA], [https://pdbe.org/4f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f11 RCSB], [https://www.ebi.ac.uk/pdbsum/4f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f11 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GABR2_HUMAN GABR2_HUMAN] Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.<ref>PMID:9872316</ref> <ref>PMID:10328880</ref> <ref>PMID:18165688</ref> <ref>PMID:22660477</ref>  

*[[GABA receptor 3D structures|GABA receptor 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Burmakina S]]

[[Category: Bush M]]

[[Category: Chen Y]]

[[Category: Fan QR]]

[[Category: Geng Y]]

[[Category: Javitch JA]]

[[Category: Kniazeff J]]

[[Category: Malito DL]]

[[Category: Mosyak L]]

[[Category: Pin J-P]]

[[Category: Quick M]]

[[Category: Xiong D]]