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==Kainate bound to the D655A mutant of the ligand binding domain of GluA3==
==Kainate bound to the D655A mutant of the ligand binding domain of GluA3==
<StructureSection load='4f31' size='340' side='right' caption='[[4f31]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4f31' size='340' side='right'caption='[[4f31]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F31 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F31 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f1y|4f1y]], [[4f22|4f22]], [[4f29|4f29]], [[4f2o|4f2o]], [[4f2q|4f2q]], [[4f39|4f39]], [[4f3b|4f3b]], [[4f3g|4f3g]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f31 OCA], [https://pdbe.org/4f31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f31 RCSB], [https://www.ebi.ac.uk/pdbsum/4f31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f31 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Glur3, Gria3, Gria3; GluA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f31 OCA], [http://pdbe.org/4f31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f31 RCSB], [http://www.ebi.ac.uk/pdbsum/4f31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f31 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).  
[https://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4f31" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4f31" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Ahmed, A H]]
[[Category: Rattus norvegicus]]
[[Category: Oswald, R E]]
[[Category: Ahmed AH]]
[[Category: Ampa receptor]]
[[Category: Oswald RE]]
[[Category: Glua3]]
[[Category: Glur3]]
[[Category: Glutamate receptor]]
[[Category: Kainate]]
[[Category: Lbd]]
[[Category: Neurotransmitter receptor]]
[[Category: S1s2]]
[[Category: Transport protein-agonist complex]]
Retrieved from "https://proteopedia.org/4f31"