4f5c: Difference between revisions

<StructureSection load='4f5c' size='340' side='right'caption='[[4f5c]], [[Resolution|resolution]] 3.20&Aring;' scene=''>

<table><tr><td colspan='2'>[[4f5c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_respiratory_coronavirus Porcine respiratory coronavirus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F5C FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5c OCA], [https://pdbe.org/4f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f5c RCSB], [https://www.ebi.ac.uk/pdbsum/4f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f5c ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/AMPN_PIG AMPN_PIG] Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines and involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide. In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.<ref>PMID:7913510</ref> <ref>PMID:1350661</ref> <ref>PMID:7911642</ref> <ref>PMID:8985407</ref> <ref>PMID:9634079</ref>  

*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]

[[Category: Large Structures]]

[[Category: Casasnovas JM]]

[[Category: Enjuanes L]]

[[Category: Gaurav M]]

[[Category: Ordono D]]

[[Category: Reguera J]]

[[Category: Santiago C]]