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==The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc==
==The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc==
<StructureSection load='4fdj' size='340' side='right' caption='[[4fdj]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='4fdj' size='340' side='right'caption='[[4fdj]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fdj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FDJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fdj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FDJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DDZ:3,3-DIHYDROXY+L-ALANINE'>DDZ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DDZ:3,3-DIHYDROXY+L-ALANINE'>DDZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fdj OCA], [https://pdbe.org/4fdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fdj RCSB], [https://www.ebi.ac.uk/pdbsum/4fdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fdj ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fdi|4fdi]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GALNS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylgalactosamine-6-sulfatase N-acetylgalactosamine-6-sulfatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.4 3.1.6.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fdj OCA], [http://pdbe.org/4fdj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fdj RCSB], [http://www.ebi.ac.uk/pdbsum/4fdj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fdj ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/GALNS_HUMAN GALNS_HUMAN]] Mucopolysaccharidosis type 4A. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/GALNS_HUMAN GALNS_HUMAN] Mucopolysaccharidosis type 4A. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/GALNS_HUMAN GALNS_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Sulfatase|Sulfatase]]
*[[Sulfatase 3D structures|Sulfatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: N-acetylgalactosamine-6-sulfatase]]
[[Category: Large Structures]]
[[Category: Garman, S C]]
[[Category: Garman SC]]
[[Category: Rivera-Colon, Y]]
[[Category: Rivera-Colon Y]]
[[Category: Carbohydrate-binding protein]]
[[Category: Enzyme replacement therapy]]
[[Category: Formylglycine]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Lysosomal enzyme]]
[[Category: N-linked glycosylation]]
[[Category: Sulfatase]]
Retrieved from "https://proteopedia.org/4fdj"