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==Sulfatase from Mycobacterium tuberculosis==
==Sulfatase from Mycobacterium tuberculosis==
<StructureSection load='4ffa' size='340' side='right' caption='[[4ffa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4ffa' size='340' side='right'caption='[[4ffa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ffa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ffa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3514, MTCY78.22c, Rv3406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffa OCA], [https://pdbe.org/4ffa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffa RCSB], [https://www.ebi.ac.uk/pdbsum/4ffa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffa OCA], [http://pdbe.org/4ffa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ffa RCSB], [http://www.ebi.ac.uk/pdbsum/4ffa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATSK_MYCTU ATSK_MYCTU] Alpha-ketoglutarate-dependent sulfate ester dioxygenase, which oxidizes medium-chain alkyl-sulfate esters (PubMed:23762287). Shows preference for 2-ethylhexyl sulfate (2-EHS) in vitro, leading to the formation of succinate and 2-ethylhexanal (PubMed:23762287, PubMed:25427196). Has likely a role in sulfate scavenging in vivo (PubMed:23762287).<ref>PMID:23762287</ref> <ref>PMID:25427196</ref>  Also causes the inactivation of the 2-carboxyquinoxaline Ty38c (an antitubercular compound that inhibits DprE1) via oxidative decarboxylation, using Ty38c instead of alpha-ketoglutarate as a substrate. Is thus responsible for primary resistance of M.tuberculosis to Ty38c in vitro. Overexpression of Rv3406 causes resistance to Ty38c.<ref>PMID:25427196</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Sulfatase|Sulfatase]]
*[[Sulfatase 3D structures|Sulfatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bertozzi, C R]]
[[Category: Large Structures]]
[[Category: Breidenbach, M A]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Gartner, Z J]]
[[Category: Bertozzi CR]]
[[Category: Sogi, K M]]
[[Category: Breidenbach MA]]
[[Category: Alkyl sulfatase]]
[[Category: Gartner ZJ]]
[[Category: Dioxygenase]]
[[Category: Sogi KM]]
[[Category: Jelly roll]]
[[Category: Oxidoreductase]]
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