8cz5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8cz5 is ~~ON HOLD until 2024~~-05-24

==N11 P domain 2D9 Fab P complex==

~~Authors~~: ~~Leuthold~~, M., ~~Kilic~~, T., ~~Hansman~~, G.

== Structural highlights ==

<table><tr><td colspan='2'>[[8cz5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lagovirus Lagovirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZ5 FirstGlance]. <br>

~~Description~~: ~~N11 P domain 2D9 Fab P complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cz5 OCA], [https://pdbe.org/8cz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cz5 RCSB], [https://www.ebi.ac.uk/pdbsum/8cz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cz5 ProSAT]</span></td></tr>

[[Category: ~~Kilic, T~~]]

</table>

[[Category: Hansman, G]]

== Function ==

[[Category: Leuthold, M]]

[https://www.uniprot.org/uniprot/A0A0B5CYZ3_RHDV A0A0B5CYZ3_RHDV] 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.[ARBA:ARBA00003176] Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.[ARBA:ARBA00024666] NTPase presumably plays a role in replication.[ARBA:ARBA00002279] Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.[ARBA:ARBA00025359]

__TOC__

</StructureSection>

[[Category: Lagovirus]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Hansman G]]

[[Category: Kilic T]]

[[Category: Leuthold M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8cz5 is ON HOLD  until 2024-05-24
+==N11 P domain 2D9 Fab P complex==
+<StructureSection load='8cz5' size='340' side='right'caption='[[8cz5]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-Authors: Leuthold, M., Kilic, T., Hansman, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8cz5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lagovirus Lagovirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZ5 FirstGlance]. <br>
-Description: N11 P domain 2D9 Fab P complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cz5 OCA], [https://pdbe.org/8cz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cz5 RCSB], [https://www.ebi.ac.uk/pdbsum/8cz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cz5 ProSAT]</span></td></tr>
-[[Category: Kilic, T]]
+</table>
-[[Category: Hansman, G]]
+== Function ==
-[[Category: Leuthold, M]]
+[https://www.uniprot.org/uniprot/A0A0B5CYZ3_RHDV A0A0B5CYZ3_RHDV] 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.[ARBA:ARBA00003176]  Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.[ARBA:ARBA00024666]  NTPase presumably plays a role in replication.[ARBA:ARBA00002279]  Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.[ARBA:ARBA00025359]
+__TOC__
+</StructureSection>
+[[Category: Lagovirus]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Hansman G]]
+[[Category: Kilic T]]
+[[Category: Leuthold M]]