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==Crystal structure of prolegumain==
==Crystal structure of prolegumain==
<StructureSection load='4fgu' size='340' side='right' caption='[[4fgu]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
<StructureSection load='4fgu' size='340' side='right'caption='[[4fgu]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fgu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FGU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fgu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FGU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4aw9|4aw9]], [[4awa|4awa]], [[4awb|4awb]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgu OCA], [https://pdbe.org/4fgu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fgu RCSB], [https://www.ebi.ac.uk/pdbsum/4fgu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgu ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGMN, PRSC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Legumain Legumain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.34 3.4.22.34] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgu OCA], [http://pdbe.org/4fgu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fgu RCSB], [http://www.ebi.ac.uk/pdbsum/4fgu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.  
[https://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Legumain]]
[[Category: Large Structures]]
[[Category: Brandstetter, H]]
[[Category: Brandstetter H]]
[[Category: Dall, E]]
[[Category: Dall E]]
[[Category: Aep]]
[[Category: Antigen processing]]
[[Category: Asparaginyl endopeptidase]]
[[Category: Cancer]]
[[Category: Cysteine protease]]
[[Category: Hydrolase]]
[[Category: Lysosomal]]
[[Category: Mhcii]]
[[Category: Proenzyme]]
[[Category: Substrate specificity]]
Retrieved from "https://proteopedia.org/4fgu"