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==Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound==
==Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound==
<StructureSection load='4fia' size='340' side='right' caption='[[4fia]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4fia' size='340' side='right'caption='[[4fia]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FIA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FIA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0U9:S-BICALUTAMIDE'>0U9</scene>, <scene name='pdbligand=198:R-BICALUTAMIDE'>198</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0U9:S-BICALUTAMIDE'>0U9</scene>, <scene name='pdbligand=198:R-BICALUTAMIDE'>198</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q9f|2q9f]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fia OCA], [https://pdbe.org/4fia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fia RCSB], [https://www.ebi.ac.uk/pdbsum/4fia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fia ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP46, CYP46A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholesterol_24-hydroxylase Cholesterol 24-hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.98 1.14.13.98] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fia OCA], [http://pdbe.org/4fia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fia RCSB], [http://www.ebi.ac.uk/pdbsum/4fia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fia ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.  
[https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cholesterol 24-hydroxylase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Mast, N]]
[[Category: Mast N]]
[[Category: Pikuleva, I A]]
[[Category: Pikuleva IA]]
[[Category: Stout, C D]]
[[Category: Stout CD]]
[[Category: Bicalutamide complex]]
[[Category: Cyp46a1]]
[[Category: Cytochrome p450]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/4fia"