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==Crystal structure of human RPRD1B, carboxy-terminal domain==
==Crystal structure of human RPRD1B, carboxy-terminal domain==
<StructureSection load='4fla' size='340' side='right' caption='[[4fla]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4fla' size='340' side='right'caption='[[4fla]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FLA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fla]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FLA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RPRD1B, C20orf77, CREPT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fla OCA], [https://pdbe.org/4fla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fla RCSB], [https://www.ebi.ac.uk/pdbsum/4fla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fla ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fla OCA], [http://pdbe.org/4fla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fla RCSB], [http://www.ebi.ac.uk/pdbsum/4fla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fla ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RPR1B_HUMAN RPR1B_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.<ref>PMID:22264791</ref> <ref>PMID:22231121</ref>
[https://www.uniprot.org/uniprot/RPR1B_HUMAN RPR1B_HUMAN] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.<ref>PMID:22264791</ref> <ref>PMID:22231121</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bakkouri, M El]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Greenblatt, J F]]
[[Category: El Bakkouri M]]
[[Category: Guo, X]]
[[Category: Greenblatt JF]]
[[Category: Loppnau, P]]
[[Category: Guo X]]
[[Category: Min, J]]
[[Category: Loppnau P]]
[[Category: Ni, Z]]
[[Category: Min J]]
[[Category: Structural genomic]]
[[Category: Ni Z]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Xu, C]]
[[Category: Xu C]]
[[Category: Sgc]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4fla"