4g0o: Difference between revisions

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==Crystal structure of Arabidopsis thaliana AGO5 MID domain==
==Crystal structure of Arabidopsis thaliana AGO5 MID domain==
<StructureSection load='4g0o' size='340' side='right' caption='[[4g0o]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='4g0o' size='340' side='right'caption='[[4g0o]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4g0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4g0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g0m|4g0m]], [[4g0p|4g0p]], [[4g0q|4g0q]], [[4g0x|4g0x]], [[4g0y|4g0y]], [[4g0z|4g0z]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0o OCA], [https://pdbe.org/4g0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0o RCSB], [https://www.ebi.ac.uk/pdbsum/4g0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGO5, At2g27880, T1E2.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0o OCA], [http://pdbe.org/4g0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g0o RCSB], [http://www.ebi.ac.uk/pdbsum/4g0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AGO5_ARATH AGO5_ARATH]] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates with siRNAs of various sizes, from 21-24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal cytosine. Probably involved in antiviral RNA silencing. Associates with siRNAs derived from cucumber mosaic virus (CMV). Targeted by the turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO5 function in RNA silencing.<ref>PMID:17869110</ref> <ref>PMID:18342361</ref> <ref>PMID:18344228</ref>
[https://www.uniprot.org/uniprot/AGO5_ARATH AGO5_ARATH] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates with siRNAs of various sizes, from 21-24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal cytosine. Probably involved in antiviral RNA silencing. Associates with siRNAs derived from cucumber mosaic virus (CMV). Targeted by the turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO5 function in RNA silencing.<ref>PMID:17869110</ref> <ref>PMID:18342361</ref> <ref>PMID:18344228</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Argonaute|Argonaute]]
*[[Argonaute 3D structures|Argonaute 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Frank, F]]
[[Category: Large Structures]]
[[Category: Hauver, J]]
[[Category: Frank F]]
[[Category: Nagar, B]]
[[Category: Hauver J]]
[[Category: Sonenberg, N]]
[[Category: Nagar B]]
[[Category: Gene regulation]]
[[Category: Sonenberg N]]
[[Category: Mid domain]]
[[Category: Small rna 5' nucleotide recognition]]
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