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==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==
==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==
<StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='4g2b' size='340' side='right'caption='[[4g2b]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g29|4g29]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [https://pdbe.org/4g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [https://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://pdbe.org/4g2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SSEI_SALTY SSEI_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.<ref>PMID:17095609</ref> <ref>PMID:19956712</ref>
[https://www.uniprot.org/uniprot/SSEI_SALTY SSEI_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.<ref>PMID:17095609</ref> <ref>PMID:19956712</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Salty]]
[[Category: Large Structures]]
[[Category: Bhaskaran, S S]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Stebbins, C E]]
[[Category: Bhaskaran SS]]
[[Category: Cysteine protease superfamily]]
[[Category: Stebbins CE]]
[[Category: Protein binding]]

Revision as of 20:21, 19 October 2022

Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI

4g2b, resolution 2.05Å

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