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==Crystal structure of s-adenosylhomocysteine nucleosidase from streptococcus pyogenes in complex with 5-methylthiotubericidin==
==Crystal structure of s-adenosylhomocysteine nucleosidase from streptococcus pyogenes in complex with 5-methylthiotubericidin==
<StructureSection load='4g41' size='340' side='right' caption='[[4g41]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='4g41' size='340' side='right'caption='[[4g41]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4g41]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_atcc_10782 Streptococcus pyogenes atcc 10782]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G41 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4g41]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_ATCC_10782 Streptococcus pyogenes ATCC 10782]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G41 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMPREF0841_1463, mtn N, mtnN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=864568 Streptococcus pyogenes ATCC 10782])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g41 OCA], [https://pdbe.org/4g41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g41 RCSB], [https://www.ebi.ac.uk/pdbsum/4g41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g41 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g41 OCA], [http://pdbe.org/4g41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g41 RCSB], [http://www.ebi.ac.uk/pdbsum/4g41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g41 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/E0PXI9_STRPY E0PXI9_STRPY]] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).[SAAS:SAAS010049_004_034880]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptococcus pyogenes atcc 10782]]
[[Category: Large Structures]]
[[Category: Anderson, B F]]
[[Category: Streptococcus pyogenes ATCC 10782]]
[[Category: Brown, R L]]
[[Category: Anderson BF]]
[[Category: Evans, G B]]
[[Category: Brown RL]]
[[Category: Frohlich, R]]
[[Category: Evans GB]]
[[Category: Norris, G E]]
[[Category: Frohlich R]]
[[Category: Ponniah, K]]
[[Category: Norris GE]]
[[Category: Tyler, P C]]
[[Category: Ponniah K]]
[[Category: Cleavage]]
[[Category: Tyler PC]]
[[Category: Hydrolase]]
[[Category: Mixed alpha/beta]]
[[Category: S-adenosylhomocysteine]]

Revision as of 20:23, 19 October 2022

Crystal structure of s-adenosylhomocysteine nucleosidase from streptococcus pyogenes in complex with 5-methylthiotubericidin

4g41, resolution 1.45Å

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