7ukz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7ukz is ~~ON HOLD until Paper Publication~~

==CDK11 in complex with small molecule inhibitor OTS964==

~~Authors~~: ~~Kelso~~, S., ~~Sicheri~~, F.

== Structural highlights ==

<table><tr><td colspan='2'>[[7ukz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UKZ FirstGlance]. <br>

~~Description~~: ~~CDK11~~ in ~~complex with small molecule inhibitor OTS964~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NK3:OTS964'>NK3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ukz OCA], [https://pdbe.org/7ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ukz RCSB], [https://www.ebi.ac.uk/pdbsum/7ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ukz ProSAT]</span></td></tr>

[[Category: ~~Sicheri, F~~]]

</table>

[[Category: Kelso, S]]

== Function ==

[https://www.uniprot.org/uniprot/CD11B_HUMAN CD11B_HUMAN] Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.<ref>PMID:12501247</ref> <ref>PMID:12624090</ref> <ref>PMID:18216018</ref> <ref>PMID:2217177</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kelso S]]

[[Category: Sicheri F]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ukz is ON HOLD  until Paper Publication
+==CDK11 in complex with small molecule inhibitor OTS964==
+<StructureSection load='7ukz' size='340' side='right'caption='[[7ukz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Kelso, S., Sicheri, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ukz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UKZ FirstGlance]. <br>
-Description: CDK11 in complex with small molecule inhibitor OTS964
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NK3:OTS964'>NK3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ukz OCA], [https://pdbe.org/7ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ukz RCSB], [https://www.ebi.ac.uk/pdbsum/7ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ukz ProSAT]</span></td></tr>
-[[Category: Sicheri, F]]
+</table>
-[[Category: Kelso, S]]
+== Function ==
+[https://www.uniprot.org/uniprot/CD11B_HUMAN CD11B_HUMAN] Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.<ref>PMID:12501247</ref> <ref>PMID:12624090</ref> <ref>PMID:18216018</ref> <ref>PMID:2217177</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kelso S]]
+[[Category: Sicheri F]]