7vn9: Difference between revisions
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==Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with C04 Fab== | |||
<StructureSection load='7vn9' size='340' side='right'caption='[[7vn9]], [[Resolution|resolution]] 4.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7vn9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VN9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vn9 OCA], [https://pdbe.org/7vn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vn9 RCSB], [https://www.ebi.ac.uk/pdbsum/7vn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vn9 ProSAT]</span></td></tr> | ||
[[Category: Xiang | </table> | ||
[[Category: Yang | == Function == | ||
[https://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Human coronavirus 229E]] | |||
[[Category: Large Structures]] | |||
[[Category: Xiang JC]] | |||
[[Category: Yang B]] | |||
