7vng: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7vng is ~~ON HOLD until Paper Publication~~

==Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with S11 Fab==

~~Authors~~: ~~Xiang~~, J.C., ~~Zhao~~, W.W., ~~Yang~~, B.

== Structural highlights ==

<table><tr><td colspan='2'>[[7vng]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VNG FirstGlance]. <br>

~~Description~~: ~~Crystal~~ structure of ~~human~~ coronavirus 229E ~~spike protein receptor-binding domain in complex with S11 Fab~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vng OCA], [https://pdbe.org/7vng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vng RCSB], [https://www.ebi.ac.uk/pdbsum/7vng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vng ProSAT]</span></td></tr>

[[Category: Xiang~~, J.C~~]]

</table>

[[Category: ~~Zhao, W.W~~]]

== Function ==

[[Category: ~~Yang, B~~]]

[https://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Human coronavirus 229E]]

[[Category: Large Structures]]

[[Category: Xiang JC]]

[[Category: Yang B]]

[[Category: Zhao WW]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7vng is ON HOLD  until Paper Publication
+==Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with S11 Fab==
+<StructureSection load='7vng' size='340' side='right'caption='[[7vng]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-Authors: Xiang, J.C., Zhao, W.W., Yang, B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7vng]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VNG FirstGlance]. <br>
-Description: Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with S11 Fab
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vng OCA], [https://pdbe.org/7vng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vng RCSB], [https://www.ebi.ac.uk/pdbsum/7vng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vng ProSAT]</span></td></tr>
-[[Category: Xiang, J.C]]
+</table>
-[[Category: Zhao, W.W]]
+== Function ==
-[[Category: Yang, B]]
+[https://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Human coronavirus 229E]]
+[[Category: Large Structures]]
+[[Category: Xiang JC]]
+[[Category: Yang B]]
+[[Category: Zhao WW]]