1is5: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1is5.jpg|left|200px]] | [[Image:1is5.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1is5", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_1is5| PDB=1is5 | SCENE= }} | |||
}} | |||
'''Ligand free Congerin II''' | '''Ligand free Congerin II''' | ||
| Line 33: | Line 30: | ||
[[Category: Shirai, T.]] | [[Category: Shirai, T.]] | ||
[[Category: Yamane, T.]] | [[Category: Yamane, T.]] | ||
[[Category: | [[Category: Beta sandwich]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:58 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:20, 2 May 2008
Ligand free Congerin II
Overview
The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.
About this Structure
1IS5 is a Single protein structure of sequence from Conger myriaster. Full crystallographic information is available from OCA.
Reference
Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:12206768 Page seeded by OCA on Fri May 2 20:20:58 2008
