7tvg: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of SHOC2 to a resolution of 2.4 Angstrom== | ==Crystal Structure of SHOC2 to a resolution of 2.4 Angstrom== | ||
<StructureSection load='7tvg' size='340' side='right'caption='[[7tvg]]' scene=''> | <StructureSection load='7tvg' size='340' side='right'caption='[[7tvg]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TVG FirstGlance]. <br> | <table><tr><td colspan='2'>[[7tvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TVG FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tvg OCA], [https://pdbe.org/7tvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tvg RCSB], [https://www.ebi.ac.uk/pdbsum/7tvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tvg ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tvg OCA], [https://pdbe.org/7tvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tvg RCSB], [https://www.ebi.ac.uk/pdbsum/7tvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tvg ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bonsor DA]] | [[Category: Bonsor DA]] | ||
[[Category: Simanshu DK]] | [[Category: Simanshu DK]] | ||
