7w6l: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 06:27, 26 October 2022
The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide
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