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==The crystal structure of human fascin 1 K358A mutant==
==The crystal structure of human fascin 1 K358A mutant==
<StructureSection load='4gp3' size='340' side='right' caption='[[4gp3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='4gp3' size='340' side='right'caption='[[4gp3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gp3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GP3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GP3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gp0|4gp0]], [[4gov|4gov]], [[4goy|4goy]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gp3 OCA], [https://pdbe.org/4gp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gp3 RCSB], [https://www.ebi.ac.uk/pdbsum/4gp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gp3 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAN1, FSCN1, HSN, SNL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gp3 OCA], [http://pdbe.org/4gp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gp3 RCSB], [http://www.ebi.ac.uk/pdbsum/4gp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gp3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN]] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref>
[https://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4gp3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4gp3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Fascin|Fascin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chen, L]]
[[Category: Large Structures]]
[[Category: Chen, S]]
[[Category: Chen L]]
[[Category: Diaz-Avalos, R]]
[[Category: Chen S]]
[[Category: Huang, F K]]
[[Category: Diaz-Avalos R]]
[[Category: Huang, J]]
[[Category: Huang FK]]
[[Category: Huang, X Y]]
[[Category: Huang J]]
[[Category: Jakoncic, J]]
[[Category: Huang XY]]
[[Category: Leo-Macias, A]]
[[Category: Jakoncic J]]
[[Category: Yang, S Y]]
[[Category: Leo-Macias A]]
[[Category: Zhang, J J]]
[[Category: Yang SY]]
[[Category: Actin]]
[[Category: Zhang JJ]]
[[Category: Actin bundling protein]]
[[Category: Actin-binding]]
[[Category: Beta-trefoil]]
[[Category: Cancer]]
[[Category: Cell migration]]
[[Category: Metastasis]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/4gp3"