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==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==
==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==
<StructureSection load='4gqs' size='340' side='right' caption='[[4gqs]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
<StructureSection load='4gqs' size='340' side='right'caption='[[4gqs]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r9o|1r9o]], [[1og2|1og2]], [[1og5|1og5]], [[1pq2|1pq2]], [[2nnj|2nnj]], [[2nni|2nni]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [https://pdbe.org/4gqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [https://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2C19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [http://pdbe.org/4gqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [http://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN]] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity.
[https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN]] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.  
[https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Cytochrome P450|Cytochrome P450]]
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Johnson, E F]]
[[Category: Large Structures]]
[[Category: Reynald, R L]]
[[Category: Johnson EF]]
[[Category: Sansen, S]]
[[Category: Reynald RL]]
[[Category: Stout, C D]]
[[Category: Sansen S]]
[[Category: Drug metabolizing enzyme]]
[[Category: Stout CD]]
[[Category: Heme protein]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
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