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==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycan==
==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycan==
<StructureSection load='4gu3' size='340' side='right' caption='[[4gu3]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='4gu3' size='340' side='right'caption='[[4gu3]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gu3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mrv-1 Mrv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GU3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gu3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GU3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu3 OCA], [https://pdbe.org/4gu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gu3 RCSB], [https://www.ebi.ac.uk/pdbsum/4gu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu3 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s6x|3s6x]], [[1kke|1kke]], [[4gu4|4gu4]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10884 MRV-1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu3 OCA], [http://pdbe.org/4gu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4gu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).  
[https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4gu3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4gu3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mrv-1]]
[[Category: Large Structures]]
[[Category: Reiss, K]]
[[Category: Mammalian orthoreovirus 1 Lang]]
[[Category: Stehle, T]]
[[Category: Reiss K]]
[[Category: Beta-barrel]]
[[Category: Stehle T]]
[[Category: Beta-spiral repeat]]
[[Category: Gm2 glycan junctional adhesion molecule some]]
[[Category: Greek key motif]]
[[Category: Triple beta-spiral]]
[[Category: Viral attachment protein]]
[[Category: Viral capsid]]
[[Category: Viral protein]]
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