4gvj: Difference between revisions

<StructureSection load='4gvj' size='340' side='right' caption='[[4gvj]], [[Resolution|resolution]] 2.03&Aring;' scene=''>

<table><tr><td colspan='2'>[[4gvj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GVJ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gvj OCA], [http://pdbe.org/4gvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gvj RCSB], [http://www.ebi.ac.uk/pdbsum/4gvj PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.  

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>

*[[Tyrosine kinase|Tyrosine kinase]]

[[Category: Human]]

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Abbema, A V]]

[[Category: Bao, L]]

[[Category: Barrett, K]]

[[Category: Beresini, M]]

[[Category: Berezhkovskiy, L]]

[[Category: Blair, W]]

[[Category: Chang, C]]

[[Category: Driscoll, J]]

[[Category: Eigenbrot, C]]

[[Category: Ghilardi, N]]

[[Category: Gibbons, P]]

[[Category: Halladay, J]]

[[Category: Johnson, A]]

[[Category: Kohli, P B]]

[[Category: Lai, Y]]

[[Category: Liang, J]]

[[Category: Liimatta, M]]

[[Category: Magnuson, S]]

[[Category: Mantik, P]]

[[Category: Menghrajani, K]]

[[Category: Murray, J]]

[[Category: Sambrone, A]]

[[Category: Shao, Y]]

[[Category: Shia, S]]

[[Category: Shin, Y]]

[[Category: Smith, J]]

[[Category: Sohn, S]]

[[Category: Stanley, M]]

[[Category: Tsui, V]]

[[Category: Ultsch, M]]

[[Category: Wu, L]]

[[Category: Zhang, B]]

[[Category: Kinase]]