7px5: Difference between revisions
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==ATAD2 in complex with 1-Methyl-2-quinolone== | |||
<StructureSection load='7px5' size='340' side='right'caption='[[7px5]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7px5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PX5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12Q:1-METHYLQUINOLIN-2(1H)-ONE'>12Q</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7px5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7px5 OCA], [https://pdbe.org/7px5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7px5 RCSB], [https://www.ebi.ac.uk/pdbsum/7px5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7px5 ProSAT]</span></td></tr> | ||
[[Category: Martin | </table> | ||
[[Category: Noble | == Function == | ||
[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Martin MP]] | |||
[[Category: Noble MEN]] | |||
Revision as of 07:11, 3 November 2022
ATAD2 in complex with 1-Methyl-2-quinolone
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