7pzu: Difference between revisions

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'''Unreleased structure'''


The entry 7pzu is ON HOLD  until Paper Publication
==LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria==
 
<StructureSection load='7pzu' size='340' side='right'caption='[[7pzu]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7pzu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PZU FirstGlance]. <br>
Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=99I:(2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((3-fluoro-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide'>99I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pzu OCA], [https://pdbe.org/7pzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pzu RCSB], [https://www.ebi.ac.uk/pdbsum/7pzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pzu ProSAT]</span></td></tr>
[[Category: Pallin, T.D]]
</table>
[[Category: Ryan, M.D]]
== Function ==
[[Category: Lamers, M.B.A.C]]
[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
[[Category: Leonard, P.M]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Lamers MBAC]]
[[Category: Leonard PM]]
[[Category: Pallin TD]]
[[Category: Ryan MD]]