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==Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1==
==Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1==
<StructureSection load='4h22' size='340' side='right' caption='[[4h22]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
<StructureSection load='4h22' size='340' side='right'caption='[[4h22]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h22]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H22 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h22]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H22 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q6q|2q6q]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h22 OCA], [https://pdbe.org/4h22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h22 RCSB], [https://www.ebi.ac.uk/pdbsum/4h22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h22 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LRRFIP1, GCF2, TRIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h22 OCA], [http://pdbe.org/4h22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h22 RCSB], [http://www.ebi.ac.uk/pdbsum/4h22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h22 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LRRF1_HUMAN LRRF1_HUMAN]] Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.<ref>PMID:10364563</ref> <ref>PMID:14522076</ref> <ref>PMID:16199883</ref> <ref>PMID:19265123</ref> <ref>PMID:9705290</ref>
[https://www.uniprot.org/uniprot/LRRF1_HUMAN LRRF1_HUMAN] Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.<ref>PMID:10364563</ref> <ref>PMID:14522076</ref> <ref>PMID:16199883</ref> <ref>PMID:19265123</ref> <ref>PMID:9705290</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Modis, Y]]
[[Category: Large Structures]]
[[Category: Nguyen, J B]]
[[Category: Modis Y]]
[[Category: Flightless-1]]
[[Category: Nguyen JB]]
[[Category: Nucleic acid sensor]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4h22"