4h2a: Difference between revisions

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==Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)==
==Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)==
<StructureSection load='4h2a' size='340' side='right' caption='[[4h2a]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='4h2a' size='340' side='right'caption='[[4h2a]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H2A FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H2A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1acc|1acc]], [[1t6b|1t6b]], [[3mhz|3mhz]], [[3tew|3tew]], [[3q8b|3q8b]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2a OCA], [https://pdbe.org/4h2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h2a RCSB], [https://www.ebi.ac.uk/pdbsum/4h2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2a ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2a OCA], [http://pdbe.org/4h2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h2a RCSB], [http://www.ebi.ac.uk/pdbsum/4h2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.  
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
 
==See Also==
*[[Anthrax protective antigen|Anthrax protective antigen]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker, P J]]
[[Category: Bacillus anthracis]]
[[Category: Sorrell, F J]]
[[Category: Large Structures]]
[[Category: Extracellular region]]
[[Category: Baker PJ]]
[[Category: Metal ion binding]]
[[Category: Sorrell FJ]]
[[Category: Protein binding]]
[[Category: Toxin]]
[[Category: Toxin delivery]]
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